However, one goal proved enough for City who picked up their sixth successive league win to move four points clear of Liverpool, who host Aston Villa later on Saturday, at the top of the standings.
Images from the English Premier League matches played on Saturday.
Two penalties by captain Ryan Giggs led Manchester United to a 3-1 win over Tottenham Hotspur that took them two points clear of Chelsea at the top of the Premier League despite being without Wayne Rooney on Saturday.
IMAGES from the EPL matches played on Wednesday.
A flash of attacking brilliance from Olivier Giroud and an emphatic header from substitute Alvaro Morata earned Chelsea a 2-0 win over struggling Southampton
Images from Sunday's English Premier League matches.
Manchester City can put a lid on what manager Mark Hughes describes as hysteria over their poor form when they host Premier League leaders Chelsea on Saturday.
Reaction to Arrizabalaga's refusal to be substituted
Manchester United's Jose Mourinho, humbled for the second time this season in front of the Chelsea fans who once idolised him, did not go quietly on Monday as he declared that he remains the London club's number one manager.
A summary of Saturday's action in the English Premier League.
Images from the UEFA Champions League matches played on Tuesday night.
Chelsea may have restored some breathing space over Manchester City with a 2-0 win over Newcastle United on Saturday but they have not regained the form that made them runaway title favourites earlier in the season.
Valencia earned a valuable 1-1 draw at Chelsea on Wednesday in a combative first leg of their Champions League quarter-final.
Four Chelsea fans who refused to allow a black man onto the Paris Metro were banned on Wednesday from attending football matches for between three and five years.
Group C leaders Barcelona should make it four wins from four matches against pointless Basel on Tuesday in the Champions League, while holders Manchester United can book their last 16 place with victory at Celtic.
Former England international Rio Ferdinand feels Everton's John Stones should pick Manchester United over Chelsea if the defender prefers more playing time.
Manchester City took another step toward the Premier League title when they brushed aside Blackburn Rovers 3-0 for their 18th successive home league win to move five points clear of Manchester United at the top of the table on Saturday.
The 23-year-old Portugal midfielder is Chelsea's fourth recruit under new manager Jose Mourinho.
Jose Mourinho felt ashamed by racist fans who pushed a black passenger off a metro train in Paris and he hopes the victim will accept an invitation to watch a game at Stamford Bridge to prove such behaviour was not a reflection of the real Chelsea.
IMAGES from Premier League matches played on Saturday.
Nuno's coaching staff have also been relieved of their duties. The club have not yet announced a replacement but British media reported former Chelsea and Inter Milan boss Antonio Conte is linked.
Striker Wayne Rooney made his long-awaited return for Manchester United on Saturday when they took advantage of defeats for title rivals Chelsea and Arsenal with a 2-0 home victory over nine-man Wigan Athletic.
Chelsea captain John Terry recovered from a fractured foot and is included in the squad for Saturday's FA Cup fifth round tie.
Liverpool frustrated by 10-man Arsenal in League Cup semi stalemate
Britain's sporting weekend was decimated by heavy snow and sub-zero temperatures with Sunday's Premier League showdown between Chelsea and Manchester United among the hundreds of fixtures to be called off.
Should Manchester United win their next two games, the gap will be cut to four points and while only a collapse of astonishing proportions would deny Manchester City the title.
Chelsea boss Jose Mourinho has no plans to let any of his English Premier League title-winning squad depart Stamford Bridge in the close season.
Barcelona coach Pep Guardiola is in danger of tarnishing his reputation as the man with the Midas touch when the holders seek to overturn a 1-0 deficit against Chelsea in Tuesday's Champions League semi-final second leg at the Nou Camp.
Fans are openly speculating that owner Roman Abramovich, a man who places notoriously high demands on his managers, could call time on Jose Mourinho's second spell at Stamford Bridge if Liverpool can inflict another defeat on the champions.
Until last season, Manchester United had never lost in the Premier League at Upton Park but the Londoners, who also triumphed at Old Trafford in May, made it two in two seasons with late goals by defenders Anton Ferdinand and Matthew Upson.
Arsenal host EPL leaders Manchester United on Sunday.
Manchester City forward Raheem Sterling struck twice as the Premier League champions beat Crystal Palace 3-1 at Selhurst Park on Sunday to go top of the table and heap pressure on title rivals Liverpool.
Manchester United stormed to the top of the Premier League on Saturday with a 4-1 thumping of Middlesbrough as Chelsea stole the limelight with a 6-0 hammering of third-placed Manchester City.
ROund up of the EPL matches played at the weekend.
England begin their World Cup group campaign against Iran on November 21.
Fernando Torres scored his first goal since October to help Chelsea crush Leicester City 5-2 and Liverpool beat Stoke City 2-1 to reach the FA Cup semi-finals on Sunday.
The German captain was officially presented with his number 13 Chelsea shirt on Tuesday.
The English Football Association has launched an investigation after Chelsea accused referee Mark Clattenburg of using 'inappropriate language' towards two of their players in Sunday's defeat by Manchester United.
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